Does glucosamine work against osteoarthritis?

Glucosamine is often used as a supplement to treat symptoms of osteoarthritis, but its effectiveness is subject to debate and research. Here is an overview of the current knowledge.

Glucosamine is a naturally occurring substance found in cartilage. It is often sold as a supplement, usually in the form of glucosamine sulfate or glucosamine hydrochloride, and sometimes in combination with chondroitin. Individuals with diabetes should also be careful, as glucosamine can affect blood sugar levels.

Some studies suggest that glucosamine, especially glucosamine sulfate, may help relieve pain and improve function in people with osteoarthritis, especially in the knee.

Other studies, including systematic reviews and meta-analyses, have found little to no evidence that glucosamine works significantly better than a placebo in reducing pain or improving joint function in osteoarthritis. The Cochrane Library, a respected source for systematic reviews, concluded that the benefits of glucosamine are likely minimal or not clinically relevant.

Although some people with osteoarthritis may experience some relief from symptoms with the use of glucosamine, the scientific evidence is mixed. It may be effective for some individuals, but it is not a guaranteed solution and does not work for everyone. It is always wise to talk to a doctor before starting any new supplement, especially if you have other medical conditions or are taking other medications.

Source: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD002946.pub2/full

Source: https://www.nccih.nih.gov/health/glucosamine-and-chondroitin-for-osteoarthritis-what-you-need-to-know

Author: Prof. Dr. Dirk Devroey - Latest update: 2023-12-11 - Copyright: Clinifacts 2025