What is cramp-fasciculation syndrome?

Cramp-fasciculation syndrome (CFS) is a rare neuromuscular disorder characterized by muscle cramps and fasciculations (muscle twitches).

These symptoms are caused by overactivity of nerves, usually without an obvious underlying cause. The syndrome is considered a benign condition because it does not lead to muscle weakness or degeneration, but can cause significant discomfort and anxiety.

The muscle cramps are intense, involuntary contractions of muscles, often in the legs. The fasciculations are visible or palpable muscle twitches, usually in the arms and legs. Cramps and fasciculations may be accompanied by muscle pain. The constant muscle activity can lead to fatigue.

The exact cause of Cramp-Fasciculation Syndrome is not fully understood, but it is often associated with hyperexcitability of the peripheral nerves, possibly due to disturbances in the nervous system or electrical impulses. Triggers can include stress, fatigue, or overuse of muscles.

Medications such as antispasmodics (for cramps) or anticonvulsants (such as gabapentin) may be prescribed to reduce the severity of symptoms. Stress reduction, adequate rest, and good electrolyte balance can help control symptoms.

Source: https://journals.lww.com/co-neurology/abstract/2021/10000/neuromuscular_hyperexcitability_syndromes.15.aspx

Author: Prof. Dr. Dirk Devroey - Latest update: 2024-09-03 - Copyright: Clinifacts 2024