Does low-dose lithium protect against dementia?

There is very limited evidence that low-dose lithium may protect against dementia, although research is still in its early stages and results are mixed.

Lithium is best known as a medication for treating bipolar disorder, but there is some evidence that it also has neuroprotective properties, which may help protect the brain from neurodegenerative diseases such as dementia and Alzheimer’s.

Lithium is thought to help protect nerve cells from damage caused by inflammation, oxidative stress, and cell breakdown, all of which play a role in the development of dementia. It also promotes the growth of new nerve cells (neurogenesis) in the hippocampus, a brain region crucial for memory and learning.

In Alzheimer’s disease, a form of dementia, abnormal buildups of tau proteins and amyloid deposits play a major role. Studies suggest that lithium can reduce the formation of these harmful proteins, helping to maintain healthy brain function.

There are studies that suggest improvements in cognitive function in people taking low doses of lithium. These doses are often lower than those used to treat bipolar disorder.

There is some encouraging research suggesting that lithium in low doses may protect against dementia . Larger clinical trials are needed to confirm these findings and establish safe dosages.

Source: https://karger.com/ene/article-abstract/87/2/93/906648/Lithium-Therapy-s-Potential-to-Lower-Dementia-Risk

Author: Prof. Dr. Dirk Devroey - Latest update: 2024-09-06 - Copyright: Clinifacts 2024