Is berberine dangerous?

While berberine is considered safe in many cases and is used as a natural supplement, it can be dangerous in some situations, especially if taken incorrectly or in excessively high doses.

Berberine can interfere with the liver enzymes (such as CYP3A4 and CYP2D6) that are involved in the metabolism of many medications. This can cause certain medications to be broken down more slowly and end up in dangerously high concentrations in the body. Berberine can interfere with blood thinners, such as warfarin, and may increase the risk of bleeding.

Berberine can cross the placenta and enter the fetal blood, which can be harmful to the baby. There is some evidence that berberine can worsen jaundice in newborns by speeding up the breakdown of red blood cells. Therefore, it is not recommended for pregnant or breastfeeding women.

Many people experience gastrointestinal side effects when taking berberine, such as nausea, vomiting, diarrhea, cramps, stomach pain, or constipation.

Because berberine can lower blood pressure, it may cause dizziness or fainting in people who already have low blood pressure or who are taking blood pressure medications. Berberine can also slow the heart rate in some cases, which can be dangerous for people with heart problems.

Although berberine appears to be generally safe for short-term use, long-term use can put a strain on the liver, especially in people who already have liver problems.

Source: https://link.springer.com/article/10.1007/s00210-024-03326-x

Author: Prof. Dr. Dirk Devroey - Latest update: 2024-09-16 - Copyright: Clinifacts 2025