How much paracetamol is dangerous?

The amount of paracetamol that is considered dangerous depends on several factors, such as age, weight, general health and any simultaneous intake of other medications or alcohol.

In adults, the recommended maximum dosage is 4 grams (4000 mg) per day, usually divided into 4 doses of 1 gram (1000 mg) each, with at least 4 hours between doses. For children, the dosage depends on body weight, usually around 10-15 mg per kilogram body weight per dose, with a maximum daily dose of about 60 mg/kg.

For an adult, a single intake of more than 7.5 to 10 grams (7500-10,000 mg) can be life-threatening and cause permanent liver damage. In children, toxicity can occur at a dose of more than 150 mg/kg. Even lower doses (for example, just over 4 grams per day) can be harmful if taken over several days. In vulnerable groups, such as people with liver disease, alcoholics or the elderly, the threshold for toxicity may be lower.

At first, symptoms may be mild or absent, but liver damage can develop within 24 to 72 hours. Possible signs include nausea and vomiting, fatigue, abdominal pain, especially in the upper right side (liver area), jaundice (yellow skin or eyes), and confusion or drowsiness in severe cases.

Call a doctor or emergency services immediately if you suspect an overdose, even if symptoms are not yet present. Prompt treatment can prevent serious complications.

Author: Prof. Dr. Dirk Devroey - Latest update: 2025-01-19 - Copyright: Clinifacts 2025