Does DHM help with a hangover?

Dihydromyricetin (DHM), also called ampelopsin, is an extract from the Japanese raisin tree that is sometimes sold as an anti-hangover remedy.

There is limited scientific evidence that DHM may have some effects on alcohol metabolism and certain symptoms, but it is not a guaranteed or proven hangover cure. Many claims in supplement marketing are exaggerated.

Animal studies indicate that DHM may slightly affect the liver enzymes that break down alcohol, and that animals became clearer more quickly after drinking alcohol.

A few small human studies suggest a possible reduction in certain hangover symptoms (such as dizziness and anxiety), but the quality of the evidence is low.

DHM does not repair the liver and does not accelerate alcohol metabolism sufficiently to actually prevent a hangover. It does not protect against alcohol-related damage. There is no convincing clinical evidence that it can prevent a hangover in humans.

DHM may interact with medications. It is often sold alongside other products (B vitamins, extracts) that have little substantiated support. It can create a false sense of security, leading people to drink more, which is actually detrimental.

DHM may offer some mild relief for certain hangover symptoms, but it's not a proven, reliable, or completely effective hangover cure. The best protection remains drinking alcohol in moderation, drinking plenty of water, and getting good sleep.

Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8603706/

Author: Prof. Dr. Dirk Devroey - Latest update: 2025-12-13 - Copyright: Clinifacts 2026